Klinik und Poliklinik
für Innere Medizin II
Klinik und Poliklinik für Innere Medizin II
Direktor: Univ.-Prof. Dr. med. Roland. M. Schmid
direktion.med2@mri.tum.de

Univ.-Prof. Dr. med. Roland M. Schmid

 

Univ.-Prof. Dr. med.

Roland M. Schmid

Leitung

 

Facharzt für Innere Medizin
Teilgebietsbezeichnung Gastroenterologie und Endokrinologie

 

Tel.: (0 89) 41 40 - 22 51 (Sekretariat)

direktion.med2@mri.tum.de

Beruflicher Werdegang und Ausbildung

seit 2018

Sprecher des Sonderforschungsbereichs SFB 1321 "Modelling and Targeting Pancreatic Cancer"

 

seit 2002

C4-Professur Innere Medizin, Schwerpunkt Gastroenterologie, Hepatologie und Endokrinologie der Technischen Universität München, Klinikum rechts der Isar, II. Medizinische Klinik

 

1997 – 2002

Leitender Oberarzt, Abteilung Innere Medizin I, Universitätsklinikum Ulm

 

1993 – 1997

Assistenzarzt Abteilung Innere Medizin I, Universität Ulm

 

1986 – 1989

Wissenschaftlicher Assistent II. Medizinische Klinik,
Klinikum rechts der Isar der Technischen Universität München

 

2001

Verleihung der Bezeichnung „außerplanmäßiger Professor“ 

 

2000

Ernennung zum Hochschuldozenten, Abteilung Innere Medizin I

 

1996

Facharzt für Innere Medizin

 

1995

Ernennung zum Privatdozenten, Medizinische Fakultät, Universität Ulm


1995

Habilitation für Innere Medizin
„Reinigung, Klonierung und Charakterisierung des Transkriptionsfaktors NF-KB“

Medizinische Fakultät, Universität Ulm

 

1987

Promotion zum Dr. med.
„Einfluß von Glucose, Insulin und Opiaten auf die neuroendokrine Regulation im Magen“ (summa cum laude)
Universität Ulm

 

1979 – 1985

Medizin-Studium an der Universität in Ulm


Weitere Qualifikationen

 

1999

Teilgebietsbezeichnung Gastroenterologie

 

2002

Teilgebietsbezeichnung Endokrinologie

 

2005

Executive EMBA, Universität St. Gallen

Preise und Auszeichnungen

2008

Heinz Maier Leibnitz Medaille der TUM

 

2005

Editorial Board of World Journal of Gastroenterology

 

2004

Editorial Board of DIGESTION

 

2002

Council International Association of Pancreatology

 

2002

Editorial Board of Gastroenterology

 

2001

Merckle-Forschungspreis der Universität Ulm

 

1998

Ludwig-Heilmeyer-Medaille in Silber,
Deutsche Gesellschaft für Fortschritte in der Inneren Medizin, Köln

 

1986

Wolf-Boas-Preis,
Deutsche Gesellschaft für Verdauungs- und Stoffwechselerkrankungen, Salzburg

Mitgliedschaften

  • Deutsche Gesellschaft für Innere Medizin
  • Deutsche Gesellschaft für Fortschritte in der Inneren Medizin
  • Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten
  • Vereinigung der Bayerischen Internisten
  • Deutsche Krebsgesellschaft
  • Deutsche Gesellschaft für Immunologie
  • Arbeitsgemeinschaft Universitärer Gastroenterologen
  • Deutscher Pankreasclub
  • Gesellschaft für Biochemie und Molekularbiologie
  • Europäischer Pankreasclub
  • International Association of Pancreatology
  • American Gastroenterological Association
  • American Society of Clinical Oncology
  • American Association of Cancer Research
  • American Pancreatic Association
  • American College of Physician Executives

Patente

Gary J. Nabel, Roland M. Schmid, Neil D. Perkins.

U.S. Patent No. RE 33,823: „Proteins useful in the regulation of NFkB-containing genes“, 1998.

Forschungsaufenthalte

1990 – 1993

Research Associate am Department of Biological Chemistry and Internal Medicine, Prof. Nabel, Howard Hughes Medical Institute,
Ann Arbor, University of Michigan Medical School

 

1998 – 1990

Research Fellow am Department of Human Genetic, Prof. Meisler, Ann Arbor, University of Michigan Medical School, USA

 

1998

Research Fellow am Department für Physiology, Ann Arbor, University of Michigan, Medical School, USA

Ausgewählte Publikationen

  1. Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018 Jul;24(7):954-960.
  2. Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, Öllinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, Götzfried J, Schuck K, Hassan Z, Arbeiter A, Schönhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Klöppel G, Cadiñanos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. Nature. 2018 Feb 1;554(7690):62-68.

  3. Grinberg-Bleyer Y, Oh H, Desrichard A, Bhatt DM, Caron R, Chan TA, Schmid RM, Klein U, Hayden MS, Ghosh S. NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Cell. 2017 Sep 7;170(6):1096-1108.e13.

  4. Lubeseder-Martellato C, Alexandrow K, Hidalgo-Sastre A, Heid I, Boos SL, Briel T, Schmid RM, Siveke JT. Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions. EBioMedicine. 2017 Feb;15:90-99.

  5. Hidalgo-Sastre A, Brodylo RL, Lubeseder-Martellato C, Sipos B, Steiger K, Lee M, von Figura G, Grünwald B, Zhong S, Trajkovic-Arsic M, Neff F, Schmid RM, Siveke JT. Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model. Am J Pathol. 2016 Nov;186(11):2934-2944.
  6. Wörmann SM, Song L, Ai J, Diakopoulos KN, Kurkowski MU, Görgülü K, Ruess D, Campbell A, Doglioni C, Jodrell D, Neesse A, Demir IE, Karpathaki AP, Barenboim M, Hagemann T, Rose-John S, Sansom O, Schmid RM, Protti MP, Lesina M, Algül H. Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. Gastroenterology. 2016 Jul;151(1):180-193.e12.
  7. Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M, Steiger K, Heid I, Mueller S, Maresch R, Engleitner T, Gross N, Geumann U, Fu B, Segler A, Yuan D, Lange S, Strong A, de la Rosa J, Esposito I, Liu P, Cadiñanos J, Vassiliou GS, Schmid RM, Schneider G, Unger K, Yang F, Braren R, Heikenwälder M, Varela I, Saur D, Bradley A, Rad R. CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13982-7.
  8. Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015 Oct;21(10):1163-71.
  9. Jörs S, Jeliazkova P, Ringelhan M, Thalhammer J, Dürl S, Ferrer J, Sander M, Heikenwalder M, Schmid RM, Siveke JT, Geisler F. Lineage fate of ductular reactions in liver injury and carcinogenesis. J Clin Invest. 2015 Jun;125(6):2445-57.

  10. von Burstin J, Diersch S, Schneider G, Reichert M, Rustgi AK, Schmid RM. Detection of Tumor Suppressor Genes in Cancer Development by a Novel shRNA-Based Method. Mol Cancer Res. 2015 May;13(5):863-9.
  11. Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Öllinger R, Zukowska M, Barenboim M, Maresch R, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, Ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassiliou G, Esposito I, Liu P, Saur D, Bradley A. A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nat Genet. 2015 Jan;47(1):47-56.

  12. Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy AM, Banerjee R, Yang F, Lee CL, Moding EJ, Kirsch DG, Scheideler A, Alessi DR, Varela I, Bradley A, Kind A, Schnieke AE, Rodewald HR, Rad R, Schmid RM, Schneider G, Saur D. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov;20(11):1340-1347

  13. Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013 Jan 17;152(1-2):25-38.

  14. A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D, Bradley A. Cancer Cell. 2013 Jul 8;24(1):15-29.
  15. Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Jeliazkova P, Jörs S, Lee M, Zimber-Strobl U, Ferrer J, Schmid RM, Siveke JT, Geisler F. Hepatology. 2013 Jun;57(6):2469-79.
  16. Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D. Cancer Cell. 2013 Mar 18;23(3):406-20.
  17. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H. J Clin Invest. 2013 Mar 1;123(3):1019-31.
  18. Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A. Neuhöfer P, Liang S, Einwächter H, Schwerdtfeger C, Wartmann T, Treiber M, Zhang H, Schulz HU, Dlubatz K, Lesina M, Diakopoulos KN, Wörmann S, Halangk W, Witt H, Schmid RM, Algül H. Gastroenterology. 2013 Jan;144(1):192-201.
  19. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Santoro A, Rimassa L, Borbath I, Daniele B, Salvagni S, Van Laethem JL, Van Vlierberghe H, Trojan J, Kolligs FT, Weiss A, Miles S, Gasbarrini A, Lencioni M, Cicalese L, Sherman M, Gridelli C, Buggisch P, Gerken G, Schmid RM, Boni C, Personeni N, Hassoun Z, Abbadessa G, Schwartz B, Von Roemeling R, Lamar ME, Chen Y, Porta C. Lancet Oncol. 2013 Jan;14(1):55-63.
  20. Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Klein S, Seidler B, Kettenberger A, Sibaev A, Rohn M, Feil R, Allescher HD, Vanderwinden JM, Hofmann F, Schemann M, Rad R, Storr MA, Schmid RM, Schneider G, Saur D. Nat Commun. 2013;4:1630
  21. A porcine model of familial adenomatous polyposis. Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D, Schnieke A. Gastroenterology. 2012 Nov;143(5):1173-5.
  22. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT. Cancer Cell. 2012 Sep 11;22(3):304-17.
  23. GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation. Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H. J Biol Chem. 2012 Aug 24;287(35):29227-36.
  24. Capnographic monitoring reduces the incidence of arterial oxygen desaturation and hypoxemia during propofol sedation for colonoscopy: a randomized, controlled study (ColoCap Study). Beitz A, Riphaus A, Meining A, Kronshage T, Geist C, Wagenpfeil S, Weber A, Jung A, Bajbouj M, Pox C, Schneider G, Schmid RM, Wehrmann T, von Delius S. Am J Gastroenterol. 2012 Aug;107(8):1205-12.
  25. Production of avian retroviruses and tissue-specific somatic retroviral gene transfer in vivo using the RCAS/TVA system. von Werder A, Seidler B, Schmid RM, Schneider G, Saur D. Nat Protoc. 2012 May 24;7(6):1167-83.
  26. Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice. Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. J Clin Invest. 2012 May 1;122(5):1758-63.
  27. CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. Heiseke AF, Faul AC, Lehr HA, Förster I, Schmid RM, Krug AB, Reindl W. Gastroenterology. 2012 Feb;142(2):335-45.
  28. TFAP2E-DKK4 and chemoresistance in colorectal cancer. Ebert MP, Tänzer M, Balluff B, Burgermeister E, Kretzschmar AK, Hughes DJ, Tetzner R, Lofton-Day C, Rosenberg R, Reinacher-Schick AC, Schulmann K, Tannapfel A, Hofheinz R, Röcken C, Keller G, Langer R, Specht K, Porschen R, Stöhlmacher-Williams J, Schuster T, Ströbel P, Schmid RM.N Engl J Med. 2012 Jan 5;366(1):44-53.
  29. MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer. Balluff B, Rauser S, Meding S, Elsner M, Schöne C, Feuchtinger A, Schuhmacher C, Novotny A, Jütting U, Maccarrone G, Sarioglu H, Ueffing M, Braselmann H, Zitzelsberger H, Schmid RM, Höfler H, Ebert MP, Walch A.
    Am J Pathol. 2011 Dec;179(6):2720-9.
  30. Incidence of acute pancreatitis does not increase during Oktoberfest, but is higher than previously described in Germany. Phillip V, Huber W, Hagemes F, Lorenz S, Matheis U, Preinfalk S, Schuster T, Lippl F, Saugel B, Schmid RM.Clin Gastroenterol Hepatol. 2011 Nov;9(11):995-1000.
  31. Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis. Treiber M, Neuhöfer P, Anetsberger E, Einwächter H, Lesina M, Rickmann M, Liang S, Kehl T, Nakhai H, Schmid RM, Algül H. Gastroenterology. 2011 Oct;141(4):1473-85.
  32. Early requirement of Rac1 in a mouse model of pancreatic cancer. Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT. Gastroenterology. 2011 Aug;141(2):719-30.
  33. The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain. Burgermeister E, Friedrich T, Hitkova I, Regel I, Einwächter H, Zimmermann W, Röcken C, Perren A, Wright MB, Schmid RM, Seger R, Ebert MP. Mol Cell Biol. 2011 Aug;31(16):3497-510.
  34. In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging. Eser S, Messer M, Eser P, von Werder A, Seidler B, Bajbouj M, Vogelmann R, Meining A, von Burstin J, Algül H, Pagel P, Schnieke AE, Esposito I, Schmid RM, Schneider G, Saur D. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9945-50.
  35. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H. Cancer Cell. 2011 Apr 12;19(4):456-69.
  36. RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells. Powolny-Budnicka I, Riemann M, Tänzer S, Schmid RM, Hehlgans T, Weih F. Immunity. 2011 Mar 25;34(3):364-74.
  37. IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells. Brandl M, Seidler B, Haller F, Adamski J, Schmid RM, Saur D, Schneider G. J Cell Sci. 2010 Dec 15;123(Pt 24):4231-9
  38. IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo. Scheibel M, Klein B, Merkle H, Schulz M, Fritsch R, Greten FR, Arkan MC, Schneider G, Schmid RM. J Exp Med. 2010 Nov 22;207(12):2621-30.
  39. Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Mazur PK, Einwächter H, Lee M, Sipos B, Nakhai H, Rad R, Zimber-Strobl U, Strobl LJ, Radtke F, Klöppel G, Schmid RM, Siveke JT. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13438-43.
  40. Betacellulin protects from pancreatitis by activating stress-activated protein kinase.
    Dahlhoff M, Algül H, Siveke JT, Lesina M, Wanke R, Wartmann T, Halangk W, Schmid RM, Wolf E, Schneider MR. Gastroenterology. 2010 Apr;138(4):1585-94
  41. Argon plasma coagulation of cervical heterotopic gastric mucosa as an alternative treatment for globus sensations. Bajbouj M, Becker V, Eckel F, Miehlke S, Pech O, Prinz C, Schmid RM, Meining A. Gastroenterology. 2009 Aug;137(2):440-4.
  42. E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G, Saur D. Gastroenterology. 2009 Jul;137(1):361-71, 371.
  43. Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Rad R, Ballhorn W, Voland P, Eisenächer K, Mages J, Rad L, Ferstl R, Lang R, Wagner H, Schmid RM, Bauer S, Prinz C, Kirschning CJ, Krug A. Gastroenterology. 2009 Jun;136(7):2247-57.
  44. Validation of the X-Vision ERCP Training System and technical challenges during early training of sphincterotomy. von Delius S, Thies P, Meining A, Wagenpfeil S, Burian M, Huber W, Weidenbach H, Ebert MP, Neu B, Ludwig L, Almeida J, Prinz C, Schmid RM, Frimberger E. Clin Gastroenterol Hepatol. 2009 Apr;7(4):389-96.
  45. Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy. Xing X, Burgermeister E, Geisler F, Einwächter H, Fan L, Hiber M, Rauser S, Walch A, Röcken C, Ebeling M, Wright MB, Schmid RM, Ebert MP. Hepatology. 2009 Mar;49(3):979-88.
  46. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR. Cancer Cell. 2009 Feb 3;15(2):91-102.
  47. Auditory evoked potentials compared with bispectral index for monitoring of midazolam and propofol sedation during colonoscopy. von Delius S, Thies P, Rieder T, Wagenpfeil S, Herberich E, Karagianni A, Frimberger E, Meining A, Ludwig L, Ebert MP, Schulte-Frohlinde E, Neu B, Prinz C, Schmid RM, Huber W. Am J Gastroenterol. 2009 Feb;104(2):318-25.

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