Klinik und Poliklinik
für Innere Medizin II
Klinik und Poliklinik für Innere Medizin II
Direktor: Univ.-Prof. Dr. med. Roland. M. Schmid
direktion.med2@mri.tum.de

Principal Investigator PD Dr. Schneider

Team

Laboratory members

 

Former members

  • Dr. Rainer Hamacher rwhamacher@cnio.es
    Present: CNIO Madrid, Genes, Development and Disease Group

Research background

Although conventional chemotherapy has been one of the major medical advances for some malignancies in the last decades and the introduction of targeted molecular therapies directed against cancer-specific molecules and signaling pathways has increased therapy response and survival rates of patients with a wide variety of solid and hematological malignancies, prognosis of many gastro-intestinal cancers (GI-cancers), especially pancreatic ductal adenocarcinoma, is anymore dismal. To improve our knowledge of basic molecular changes and to develop novel therapeutic strategies, we are investigating disturbed cell cycle regulation, mechanisms of therapeutic resistance, epigenetic changes, altered signaling and metastasis in pancreatic ductal adenocarcinoma and other GI-cancers in vitro and in vivo.

Selected Publications

2018

 

  1. Z. Hassan, C. Schneeweis, M. Wirth, C. Veltkamp, Z. Dantes, B. Feuerecker, G.O. Ceyhan, S.K. Knauer, W. Weichert, R.M. Schmid, R. Stauber, A. Arlt, O.H. Krämer, R. Rad, M. Reichert, D. Saur, G. Schneider. MTOR inhibitor-based combination therapies for pancreatic cancer. British J. Cancer (2018) 118:366-377.
  2. S. Mueller, T. Engleitner, R. Maresch, M. Zukowska, S. Lange, T. Kaltenbacher, B. Konukiewitz, R. Ollinger, M. Zwiebel, A. Strong, H.Y. Yen, R. Banerjee, S. Louzada, B. Fu, B. Seidler, J. Gotzfried, K. Schuck, Z. Hassan, A. Arbeiter, N. Schonhuber, S. Klein, C. Veltkamp, M. Friedrich, L. Rad, M. Barenboim, C. Ziegenhain, J. Hess, O.M. Dovey, S. Eser, S. Parekh, F. Constantino-Casas, J. de la Rosa, M.I. Sierra, M. Fraga, J. Mayerle, G. Klöppel, J. Cadinanos, P. Liu, G. Vassiliou, W. Weichert, K. Steiger, W. Enard, R.M. Schmid, F. Yang, K. Unger, G. Schneider, I. Varela, A. Bradley, D. Saur, and R. Rad. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. Nature (2018) 554, 62-68.
  3. A. Göder, C. Emmerich, T. Nikolova , N. Kiweler , M. Schreiber , T. Kühl , D. Imhof, M. Christmann , T. Heinzel, G. Schneider, O.H. Krämer. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. Nature Communications (2018) DOI: 10.1038/s41467-018-03096-0.
  4. M. Pons, C. M. Reichardt, D. Hennig, A. Nathan, N. Kiweler, C. Stocking, C. Wichmann, M. Christmann, F. Butter, S. Reichardt, G. Schneider, T. Heinzel, C. Englert, J. Hartkamp, O. H. Krämer, N. Mahendrarajah. Loss of Wilms Tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells. Archives of Toxicology (2018) doi: 10.1007/s00204-018-2202-3.
  5. C. Schrenk, V. Fetz, C. Vallet, C. Heiselmayer, E. Schröder, A. Hensel, A. Hahlbrock, D. Wünsch, D. Goesswein, C. Bier, N. Habtemichael, G. Schneider, R.H. Stauber, S.K. Knauer. TFIIA transcriptional activity is controlled by a “cleave-and-run” Exportin-1/Taspase 1-switch. Journal of Molecular Cell Biology (2018) 10(1):33-47.
  6. M. Reichert, B. Bakir, L. Moreira, J.R. Pitarresi, K. Feldmann, L. Simon, K. Suzuki, R. Maddipati, A.D. Rhim, A.M. Schlitter, M. Kriegsmann, W. Weichert, M. Wirth, K. Schuck, G. Schneider, D. Saur, A.B. Reynolds, A. Klein-Szanto, B. Pehlivanoglu, B. Memis, N.V. Adsay, A.K. Rustgi. Regulation of epithelial plasticity determines metastatic organotropism in pancreatic cancer. Developmental Cell (2018) doi:10.1016/j.devcel.2018.05.025
  7. N. Kiweler, B. Brill, M. Wirth, I. Breuksch, T. Laguna, C. Dietrich, C. Dietrich, S. Strand, G. Schneider, B. Groner, F. Butter, W. Brenner, T. Heinzel, O.H. Krämer. The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells. Archives of Toxicology (2018) doi: 10.1007/s00204-018-2229-5.
  8. C. Geismann, W. Erhart, F. Grohmann, S. Schreiber, G. Schneider, Heiner Schäfer, A. Arlt. TRAIL/ NF-kappaB/CX3CL1 mediated onco-immuno crosstalk leading to TRAIL resistance of pancreatic cancer cell lines. International Journal of Molecular Sciences (2018) 19(6). pii: E1661.

2017

 

  1. G. Schneider, Marc Schmidt-Supprian, Roland Rad, Dieter Saur. Tissue-specific tumorigenesis - Context matters. Nature Reviews Cancer (2017) 17:239-253.
  2. N. Stojanovic, Z. Hassan, M. Wirth, P. Wenzel, M. Beyer, C. Schäfer, P. Brand, A. Kroemer, R.H. Stauber, R.M. Schmid, A. Arlt, A. Sellmer, S. Mahboobi, R. Rad, M. Reichert, D. Saur, O.H. Krämer, G. Schneider. HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer. Oncogene (2017) 36:1804-1815.
  3. C. Schäfer, A. Göder, M. Beyer, N. Kiweler, N. Mahendrarajah, A. Rauch, T. Nikolova, N. Stojanovic, M. Wieczorek, T. Reich, M.T. Tomicic, Z.-Q. Wang, M. Linnebacher, J. Sonnemann, S. Dietrich, A. Sellmer, S. Mahboobi, T. Heinzel, G. Schneider*, O.H. Krämer*. Class I histone deacetylases regulate p53/NF-kappaB crosstalk in cancer cells. Cellular Signalling (2017) 29:218-225. *equal senior author contribution
  4. C. Geismann, F. Grohmann, A. Dreher, R. Haesler, P. Rosernstiel, K. Legler, C. Hauser, J. Egberts, B. Sipos, S. Schreiber, A. Linkermann, Z. Hassan, G. Schneider, H. Schäfer, A. Arlt. Role of CCL20 mediated immune cell recruitment in NF-κB mediated TRAIL resistance of pancreatic cancer. BBA - Molecular Cell Research (2017) 1864:782-796.
  5. L. Lenk, M. Pein, O. Will, B. Gomez, F. Viol, C. Hauser, J.-H. Egberts, J.-P. Gundlach, O. Helm, S. Tiwari, R. Weiskirchen, S. Rose-John, C. Röcken, W. Mikulits, P. Wenzel, G. Schneider, D. Saur, H. Schäfer, S. Sebens. The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma. Oncoimmunology (2017) 7(1):e1368603.
  6. P. Yu, S. Petzoldt, M. Wilhelm, D. P. Zolg, R. Zheng, X. Sun, X. Liu, G. Schneider, A. Huhmer, B. Küster. Trimodal Mixed Mode Chromatography That Enables Efficient OfflineTwo-Dimensional Peptide Fractionation for Proteome Analysis. Analytical Chemistry (2017) 89: 8884-8891.
  7. B. Feuerecker, M. Durst, M. Michalik, G. Schneider, D. Saur, M. Menzel, M. Schwaiger, F. Schilling. Hyperpolarized 13C Diffusion MRS of Co-Polarized Pyruvate and Fumarate to Measure Lactate Export and Necrosis. Journal of Cancer (2017) 8: 3078-3085.

Medical theses ⎮ PhD ⎮ Grant support

Medical theses/PhD

MD theses in the research field described are available. Please send an email.



Grant support

We thank DFG, SFB 824, Deutsche Krebshilfe, Wilhelm-Sander-Stiftung, Rudolf-Bartling-Stiftung and und the DKTK Joint Funding Program for the generous support of our work.

 

                 


Contact

Head: PD Dr. med. Günter Schneider
Klinik und Poliklinik für Innere Medizin II
Klinikum rechts der Isar der TUM
Ismaninger Str. 22
81675 Munich, Germany
Tel.: +49 (0) 89 41 40 - 63 95
Fax: +49 (0) 89 41 40 - 49 10

Email: guenter.schneider@tum.de