Our group investigates the function of various intracellular signalling pathways that regulate development, homeostasis, and regeneration of the liver. The NF-B- and the Notch-pathway are central signalling pathways that control essential processes like proliferation, differentiation, and apoptosis. Using different molecular in vivo and in vitro systems we focus on studying NF-B signalling in liver inflammation, apoptosis, and regeneration. In close cooperation with AG Siveke we further seek to characterize the role of Notch-signalling in liver and bile duct development and its role in regulation of embryonic and adult liver progenitor cell growth.
Medical theses ⎮ PhD ⎮ Grant support