Klinik und Poliklinik
für Innere Medizin II
Klinik und Poliklinik für Innere Medizin II
Direktor: Univ.-Prof. Dr. med. Roland. M. Schmid

Dr. med. Dieter A. Wolf


Dr. med.

Dieter A. Wolf

Principal Investigator (Adjunct)




M.D. Degree, Department of Physiological Chemistry, Ludwig-Maximilians University Munich


State Exam in Medicine, Ludwig-Maximilians University Munich

Research & professional experience

since 2023
Full Professor, Westlake Laboratory of Life Sciences and Biomedicine, Westlake University, Hangzhou, China


since 2021

Group Leader, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University Munich, Germany


2020 – 2022
Chair Professor (visiting), School of Pharmaceutical Sciences, Xiamen University, China

since 2019
Resident & Medical Head, Biomarker Program, Medical Genetics Center Munich (MGZ), Munich, Germany

2015 – 2019

Distinguished Professor (1000 Talent Plan, part-time), School of Pharmaceutical Sciences, Xiamen University, China


2007 – 2019
Professor, Burnham Institute, La Jolla, USA, Tumor Initiation & Maintenance Program


1998 – 2007
Assistant/Associate Professor, Harvard School of Public Health

1996 – 1998
Postdoctoral Associate, Stanford University School of Medicine and Harvard Medical School


1992 – 1994
Resident-in-training, Clinic of Dermatology, Ludwig Maximilians University & collaborative research at the Institute for Clinical Molecular Biology and Tumor Genetics, Helmholtz Center Munich, Germany


1988 – 1992
Medical thesis work, Department of Physiological Chemistry. Ludwig Maximilians University, Munich, Germany
Androgen regulation of proliferation and tissue-specific gene expression in human prostate cancer cells, Thesis Adviser: Dr. Wolfram Hörz; Summa cum laude

Selected publications

  • Jain S, Hu C, Kluza J, Ke W, Bleilevels A, Tian G, Giurgiu M, Campos AR, Charbono A, Stickeler E, Maurer J, Holinski-Feder E, Vaisburg A, Bureik M, Luo G, Marchetti P, Cheng Y, Wolf DA. Targeting cancer metabolism through a ubiquinone uncompetitive inhibitor of mitochondrial complex I, (2022) Cell Chemical Biology, 29, 436-450.e15, 10.1016/j.chembiol.2021.11.002
  • Tian G, Hu Cheng, Yun Y, Yang W, Dubiel W, Cheng Y, Wolf DA. Dual roles of HSP70 chaperone HSPA1 in promoting quality control of nascent and newly synthesized proteins. (2021) EMBO J., e106183, 10.15252/embj.2020106183
  • Wang J, Dubiel D, Wu Y, Cheng Y, Wolf DA*, Dubiel W*. CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response. (2021) Cell Reports, 34: 108662, 10.1016/j.celrep.2020.108662 * Co-corresponding authors
  • Lin Y, Li F, Huang L, Polte C, Duan H, Fan J, Sun L, Xing X, Tian G, Cheng Y, Ignatova Z, Yang X, Wolf DA. eIF3 associates with 80S ribosomes to promote translation elongation, mitochondrial homeostasis, and muscle health. (2020) Molecular Cell 79, 1-13, 10.1016/j.molcel.2020.06.003
  • Shah M, Su D, Scheliga JS, Pluskal T, Boronat S, Shah M, Motamedchaboki K, Campos AR, Qi F, Yanagida M, Wolf DA. A transcript-specific eIF3 complex mediates global translational control of energy metabolism (2016), Cell Reports 16:1891-1902, 10.1016/j.celrep.2016.07.006
  • Wu S, Zhu W, Nahn T, Toth J, Petroski MD, Wolf DA. CAND1 controls in vivo dynamics of the Cullin 1-RING ubiquitin ligase repertoire (2013), Nature Communications, 4:1642, 10.1038/ncomms2636
  • Sha Z, Brill LM, Cabrera R, Kleifeld O, Glickman MH, Chang EC, Wolf DA. The eIF3 interactome reveals a supercomplex linking protein synthesis and degradation machineries (2009), Molecular Cell, 36:141-152, 10.1016/j.molcel.2009.09.026
  • Schmidt MW, McQuary PR, Wee S, Hofmann K, Wolf DA. F-box-directed CRL complex assembly and regulation by the CSN and CAND1 (2009), Molecular Cell, 35:586-597, 10.1016/j.molcel.2009.07.024
  • Wee S, Geyer R, Toda T, Wolf DA. CSN facilitates cullin/Ring ubiquitin ligase functions by counteracting autocatalytic adapter instability (2005), Nature Cell Biology 7:387-391, doi.org/10.1038/ncb1241
  • Geyer R, Wee S, Anderson S, Yates J III, Wolf DA. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. (2003) Molecular Cell 12:783-790, doi.org/10.1016/S1097-2765(03)00341-1