Neuro-psycho-gastroenterology: Principles of visceral nociception and mechanisms of microbiota-gut-brain interactions.
(contact details via Christoph Stein-Thöringer)
Visceral pain represents of the core symptoms of functional gastrointestinal disorders. Our research group is working on the development, refinement and validation of animal models of visceral nociception with a special focus on behavioral phenotyping.
Current hypotheses propose strong analogies of the development and maintenance of pain to processes underlying learning and memory. Special interest is thus set on the neurobiology of nociception to elucidate the biological signature of pain in spinal and cerebral neuronal networks.
Patients suffering from inflammatory bowel disease or gastrointestinal malignancies frequently present chronic pain syndromes and psychiatric comorbidities such as depressive episodes or anxiety disorders. Another research area focuses on the pathophysiology of visceral nociception and alterations of emotionality in clinically relevant animal models of intestinal inflammation and tumors. A detailed characterization of phenotypes is proposed a superior basis for further in depth – analyses of neurobiological, endocrine and genetic mechanisms underlying these syndromes. Using a translational approach, we are finally working on novel psychopharmacological and analgetic therapy strategies to treat visceral pain and affective disturbances in these diseases.
Publications ⎮ Medical theses ⎮ PhD
If you are interested in performing experiments and writing a master or doctoral thesis in a vibrant scientific atmosphere please contact Dr. Stein-Thöringer (cf. contact).